Re: [modeller_usage] loop modeling

[Modeller Caretaker <modeller-care@ucsf.edu>]

On 8/15/19 6:44 PM, Rui Chen wrote:
> I am using Chimera (Modeller) to model a loop, which locates at the 
> C-termini of the original crystal structure. The structure of the target 
> protein is a homodimer, however, I cannot model the two chains together. 
> How can I  model the two chains together?

I don't know if you can do it in Chimera - you would have to ask the 
Chimera folks. It is definitely possible in Modeller directly though - 
just specify both loop segments in your loop modeling script. See 
https://salilab.org/modeller/9.22/manual/node36.html in particular the 
commented-out "Too loops simultaneously" part of the script.

	Ben Webb, Modeller Caretaker
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