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Re: [modeller_usage] ligand desgin



I had difficulties running RosettaDesign plugin in Pymol, due to insufficient documentation (not sure about what executable it needs, neither which version - the plugin is not included in v3.0++, etc).

Found the server much easier provided you're patient enough...

http://rosettadesign.med.unc.edu/index.html


2010/3/2 Joel Tyndall <">>
Ditto for Pymol, etc

_________________________________
Joel Tyndall, PhD

Senior Lecturer in Medicinal Chemistry
National School of Pharmacy
University of Otago
PO Box 56 Dunedin 9054
New Zealand  
Skype: jtyndall
http://www.researcherid.com/rid/C-2803-2008
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-----Original Message-----
From: "> [mailto:">] On Behalf Of Modeller Caretaker
Sent: Wednesday, 3 March 2010 5:26 a.m.
To: Knut J Bjuland
Cc: ">
Subject: Re: [modeller_usage] ligand desgin

On 3/2/10 6:50 AM, Knut J Bjuland wrote:
> I am using a model designed with modeller to do docking. Howevere there
> is problem with ligand design. The ligand is gogin to be 4 peptides long
> and start with Ser,Ala, Gly , Val or CYS. The amino acids in the other
> postion should be any amino acid. How can I design a peptide with 20**3
> different amino acids. Or can you point me to a software that do ligand
> desing or a good database.

The last time you asked this question I told you that Modeller didn't do
protein design, and pointed you to Rosetta's design module:

http://salilab.org/archives/modeller_usage/2010/msg00051.html

Was that not suitable?

       Ben Webb, Modeller Caretaker
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