Re: [modeller_usage] Evaluation of membrane proteins models

[Modeller Caretaker <modeller-care@ucsf.edu>]

BESSADOK Anis wrote:
> I am using modeller to model MEMBRANE proteins. I want to evaluate my 
> models but I don’t know if DOPE score can be used to do this.

DOPE is a statistical potential; it was derived from a database of 
crystal structures. Thus, predictions are only likely to be reliable for 
proteins similar to those in the database. No membrane proteins were 
included in this database, so it is unlikely that DOPE in its current 
form will be reliable for the assessment of membrane protein models.

	Ben Webb, Modeller Caretaker
--
modeller-care@ucsf.edu             http://www.salilab.org/modeller/
Modeller mail list: http://salilab.org/mailman/listinfo/modeller_usage