Dear modeller members,
I want to know that can modeller build some kind of antibodies structure in which they have two chains (Vl and Vh). Actually, I have searched for some similar problems but I am still in doubt. Besides, I also found the literatures that use the modeller program to build the antibody model. Most of them did not tell more details on how they performed to obtain the antibody model. All I know from those papers are that there are two ways to performs: first, model two chains from a single template; second, model those two chains separately. Therefore, I was wondering that which one is the best method and how to do modeling by using modeller. Especially, after modeling the two chains (in case of the second method) how can I concatenate these chains?
Any comments or suggestions would be great,
Jitrayut