[modeller_usage] RE: How many models to generate?

["Frederico Arnoldi" <>]

 Hello Charlotte Habegger-Polomat,

 I am not an expert modeller user, but what I can  "share" about it?
 I think the number of models generated depends on available time and 
computational power you have to carry it. I usually generate between 100 and 
200, and select that model with the lowest "current energy".
Probably somebody could discuss it better, anyway, I tried ;)

Frederico Arnoldi
UNESP - Rio Claro - Brazil

> Dear Modeller users,
>
> I was wondering if others would share how many structures you usually
> generate for a family of models.
>
> I am currently working on modelling my protein of interest with 3 known
> template structures (>30% sequence similarity). When using Modeller, I
> generate a family of 20 models and then evaluate the variability and
> quality of models within the family.
>
> How many do other Modeller users generate?
>
> How do you decide on this number?
>
> I've read articles where 3 models, others where 30 models were generated
> with Modeller...
>
> Thanks!
>
> -Charlotte Habegger-Polomat