[modeller_usage] Loop refinement and symmetry

["David Piper" <>]

Modellers,
  When refining loops, can symmetry restraints be 
included also?
  For instance, if I have a tetrameric model protein and 
want to model a ~15 residue loop, constrain a portion of 
that loop to an alpha helix, and maintain tetrameric 
symmetry, can I simply add the special_restraints one 
would use for secondary structure and symmetry after the 
loop definition?
  I tried that approach and the resulting PDB file has 
absurdly bizarre dihdrals etc.
  Attached is an example of the .top file I tried.

  Any insight would be appreciated, thanks,

  David Piper

Attachment: TetraLoop.top
Description: Binary data