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Re: Modeling a loop



On Mon, 27 Jul 1998, Andras Fiser wrote:

> Tom Lee wrote:
> > 
> > Hi,
> > 
> > I have generated a model for my molecule.  I'm trying to study a loop
> > region in detail.  I followed the instruction in FAQ of the manual and
> > wrote the following Top file:
> > 
> > -------------------------------------------------------------------------------
> > INCLUDE
> > SET SEQUENCE              = 'ASLA2'
> > SET MODEL                 = 'ASLA2.B99990001.pdb'
> > SET ATOM_FILES_DIRECTORY  = './:../atom_files'
> > SET OUTPUT_DIRECTORY      = './'
> > SET PDB_EXT               = '.pdb'
> > SET STARTING_MODEL        = 20
> > SET ENDING_MODEL          = 29
> > SET MD_LEVEL              = 'refine1'
> > SET RAND_SEED             = -34871
> > CALL ROUTINE              = 'loop'
> > 
> > CALL ROUTINE              = 'cluster', ID1 = 20, ID2 = 29
> > 
> > SUBROUTINE ROUTINE        = 'select_atoms'
> > 
> >   PICK_ATOMS SELECTION_SEGMENT = '49:' '76:', SELECTION_STATUS = 'initialize'
> > 
> >   RETURN
> > END_SUBROUTINE
> > 
> > -----------------------------------------------------------------------------
> > 
> > "ASLA2.B99990001.pdb" is the file generated by the previous Modeler run.
> > "49" and "76" are the starting and ending residues of the loop region.
> > I got an error message after running this job:
> > 
> > -------------------------------------------------------------------------------
> > TOP______>   102  414 STRING_OPERATE OPERATION = 'CONCATENATE',                ;
> >                         STRING_ARGUMENTS = SEQUENCE '.mat',  RESULT = MATRIX_FI;
> >                       LE
> > 
> > TOP______>   103  415 SET ROOT_NAME = SEQUENCE
> > 
> > TOP______>   104  416 RETURN
> > 
> > TOP______>   105  591 STRING_OPERATE OPERATION = 'CONCATENATE',               ;
> >                         STRING_ARGUMENTS = '$(JOB).rsr',  RESULT = LOOP_CSRFILE
> > 
> > assgn___E> cannot assign a value to a value:
> > 
> > -------------------------------------------------------------------------------
> > 
> > Do you know what went wrong?
> > 
> > Thanks.
> > 
> > Tom
> 
> 
> The routine looks good, works for me with an other example than it was written
> in the manual. Check your file names and extension used by the program to be
> sure that the program reads the correct files.
> 
> include  in your top file:
> 
> SET OUTPUT_CONTROL = 1 1 1 1 
> 
> this will write out  everything to your log file,line by line, so you should
> see what goes wrong.
> 
> 
> Andras
> 
> 
> -- 
>     ,
> Andras Fiser, PhD            # phone: (212) 327 7206
> The Rockefeller University   # fax:   (212) 327 7540 
> Box 270, 1230 York Avenue    # e-mail:
> New York, NY 10021-6399, USA # http://salilab.org/~andras
> 

Thank you for the help.  I checked the filename and it was correct. 
ASLA2.B99990001.pdb is the coordinate file generated by Modeler and it is
in the working directory.  I included the SET OUTPUT_CONTROL = 1 1 1 1,
which made the TOP file look like this:
=
INCLUDE 
SET SEQUENCE = 'ASLA2' 
SET MODEL = 'ASLA2.B99990001.pdb' 
SET ATOM_FILES_DIRECTORY = './:../atom_files' 
SET OUTPUT_DIRECTORY = './'
SET OUTPUT_CONTROL = 1 1 1 1 
SET PDB_EXT = '.pdb' 
SET STARTING_MODEL = 20
SET ENDING_MODEL = 29 
SET MD_LEVEL = 'refine1' 
SET RAND_SEED = -34871 
CALL ROUTINE = 'loop'

CALL ROUTINE = 'cluster', ID1 = 20, ID2 = 29

SUBROUTINE ROUTINE = 'select_atoms'

  PICK_ATOMS SELECTION_SEGMENT = '49:' '76:', SELECTION_STATUS = 'initialize'

  RETURN
END_SUBROUTINE


However, the job was terminated the same way as before.  The .log file
looks just the same, and doesn't tell me anything more:

........

TOP______> 104 415 SET ROOT_NAME = SEQUENCE

TOP______> 105 416 RETURN

TOP______> 106 591 STRING_OPERATE OPERATION = 'CONCATENATE',              ; 
                     STRING_ARGUMENTS = '$(JOB).rsr', RESULT = LOOP_CSRFILE

assgn___E> cannot assign a value to a value:   


What does the last line mean?  I'm using the Modeler purchased from MSI.
We bought it a couple months ago.  Is it the same version as the one on
the Rockefeller web site?  Does it make any difference?  Thanks.

Tom